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Volume 21, Issue 6- g6 ]1 G9 f7 X( i( g9 d8 y! W
On the cover: The modeling of protein structures in the complete absence of
[- E; X7 m2 D- Z5 V( u7 Yany sequential similarity to any known three dimensional structure remains a
; E. Y, l9 _1 l' j) ]% d1 Wchallenging problem. Recently, it has been shown that proteins are built from a
5 r1 M* O" T6 ~! `% Klimited set of possible supersecondary structural motifs (Smotif). Menon et al.
7 g% |; \6 v7 [" H' N$ y(pp. 891–899) provide a hybrid computational algorithm in which NMR chemical
" M& }$ O$ p* \! o6 M2 p. }% Jshift information of loop segments is used to guide the selection of entire / y7 W5 A; ~- i* K
Smotifs for any given target sequence. The selected Smotifs then assemble into
4 ~% j+ l) x0 ?' O5 x7 pthree dimensional topology. Although the approach usees only backbone fragments
4 h1 \6 R" D3 x& `8 Tof Smotifs without any sequence information and limited experimental
! m/ _! H, e' C# C Z3 K v4 tinformation, it is successfully capturing the correct topologies of almost all : N& I. @+ N" G: I) w# L) Z
tested targets. The cover image was created by Mario Pujato, graduate student at
" o% y+ ]+ ?, H& xthe Albert Einstein College of Medicine, Bronx, New York.
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发表于 2013-6-10 22:28
