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Volume 21, Issue 67 q0 l6 _$ a( ]' E, q7 I
On the cover: The modeling of protein structures in the complete absence of 4 u' P3 y1 R& r/ y. k; {( r
any sequential similarity to any known three dimensional structure remains a 5 i& f% H0 k- y. p6 v
challenging problem. Recently, it has been shown that proteins are built from a
$ F1 C& V* G `- V2 ^7 u llimited set of possible supersecondary structural motifs (Smotif). Menon et al.
' t3 O4 ? F. ~(pp. 891–899) provide a hybrid computational algorithm in which NMR chemical
/ t E3 q+ @4 nshift information of loop segments is used to guide the selection of entire
/ r% \4 ^" U$ C! ^0 V9 u- M# d1 tSmotifs for any given target sequence. The selected Smotifs then assemble into
/ I% L* a! e) I0 Uthree dimensional topology. Although the approach usees only backbone fragments
E) O2 `; l* [" }# S( U% eof Smotifs without any sequence information and limited experimental 3 \- |. a2 @$ b. S
information, it is successfully capturing the correct topologies of almost all 1 k$ g, ~9 }+ c
tested targets. The cover image was created by Mario Pujato, graduate student at
: h: n ~% m u X3 R5 @% h/ gthe Albert Einstein College of Medicine, Bronx, New York.7 ~; L+ U, A: |9 b9 u, M: M
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发表于 2013-6-10 22:28
