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; f' h, I' m, JVolume 21, Issue 6
# F5 P1 N# A1 U D# u8 G7 [1 g: FOn the cover: The modeling of protein structures in the complete absence of ) Q1 A: G# y$ [4 b% w8 u, Q$ y
any sequential similarity to any known three dimensional structure remains a ! e% j2 ?# }8 p$ U/ x
challenging problem. Recently, it has been shown that proteins are built from a : o5 k9 a" t B9 b/ F z# C: ~
limited set of possible supersecondary structural motifs (Smotif). Menon et al. : d: v( A- R4 f! F
(pp. 891–899) provide a hybrid computational algorithm in which NMR chemical 3 e9 z2 D- F. @ W2 E4 i
shift information of loop segments is used to guide the selection of entire ; Q3 p- N! F- o. Z* \
Smotifs for any given target sequence. The selected Smotifs then assemble into & n6 U6 ?0 Y$ E/ O
three dimensional topology. Although the approach usees only backbone fragments , w/ ]; C+ W) a9 h4 M
of Smotifs without any sequence information and limited experimental # z4 l, d8 c1 j o. O' _
information, it is successfully capturing the correct topologies of almost all
8 J* U2 J& s, g1 }5 c0 etested targets. The cover image was created by Mario Pujato, graduate student at " K; T* f- \# Z% ]
the Albert Einstein College of Medicine, Bronx, New York.
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发表于 2013-6-10 22:28
