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 # j. E; `5 E1 a z2 o$ S
Volume 21, Issue 6
: a. m: J+ t- z6 bOn the cover: The modeling of protein structures in the complete absence of
! k2 t. c2 J6 V w! {: Eany sequential similarity to any known three dimensional structure remains a
* m1 [( w2 D) _* Y6 w. Qchallenging problem. Recently, it has been shown that proteins are built from a % q6 [( N4 Z: s
limited set of possible supersecondary structural motifs (Smotif). Menon et al.
# P2 |# z/ V/ S0 J, Q5 P, o) H(pp. 891–899) provide a hybrid computational algorithm in which NMR chemical
! ]4 f8 l) }4 P9 M, s* Nshift information of loop segments is used to guide the selection of entire
8 ^ |* M9 l, `4 G2 @7 nSmotifs for any given target sequence. The selected Smotifs then assemble into + G8 [: x9 e; Y
three dimensional topology. Although the approach usees only backbone fragments # d u4 A1 I/ v* q
of Smotifs without any sequence information and limited experimental
8 M/ f) A! L( L$ x; Pinformation, it is successfully capturing the correct topologies of almost all : M2 w& E9 q/ R) c
tested targets. The cover image was created by Mario Pujato, graduate student at
8 e, G: t, c4 k0 u! F# wthe Albert Einstein College of Medicine, Bronx, New York.
6 O/ w1 u$ r" H; m4 I6 ]% b |
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发表于 2013-6-10 22:28
