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: W3 ?2 {$ R- V
Volume 25, Issue 5* f7 r7 |& n. P% u0 @3 a
On the cover: Regulation of metabolic pathways plays a key role in controlling cell growth, proliferation, and survival in all tissues. The enzyme TIGAR acts as a fructose-2,6-bisphosphatase, promoting the pentose phosphate pathway to produce NADPH for antioxidant function and ribose-5-phosphate for nucleotide synthesis. The “eye of the tiger” on the cover shows H&E staining of TIGAR−/− intestinal tissue in an intestinal adenoma model. For more information about TIGAR's role in intestinal regeneration and tumor growth, see Cheung et al., pp. 463–477. Cover art by Pearl Lee., I" h+ {5 V3 y8 V' d6 \" n$ O$ l) W! _
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