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5 Z& N/ [8 P& j& P4 w6 H Volume 25, Issue 5
, F, u% u H2 k( ~/ ?- |3 q) gOn the cover: Regulation of metabolic pathways plays a key role in controlling cell growth, proliferation, and survival in all tissues. The enzyme TIGAR acts as a fructose-2,6-bisphosphatase, promoting the pentose phosphate pathway to produce NADPH for antioxidant function and ribose-5-phosphate for nucleotide synthesis. The “eye of the tiger” on the cover shows H&E staining of TIGAR−/− intestinal tissue in an intestinal adenoma model. For more information about TIGAR's role in intestinal regeneration and tumor growth, see Cheung et al., pp. 463–477. Cover art by Pearl Lee.3 A% u+ }7 G5 l" o% v( u
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发表于 2013-6-17 09:52
发表于 2013-6-19 19:24
