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- 积分
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- 威望
- 17983
- 包包
- 26159
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( T5 U- S) A* y3 V# K. FNaked mole rats are remarkable in $ p7 R- v, ?0 z, y7 h
combining extreme longevity with virtually complete resistance to cancer. Now a ( @- G3 g( y; D. n% b# Y2 {
novel glycosaminoglycan variant that may have evolved to provide the creatures ) ?) S7 Z+ }& ~9 w2 c9 P f6 O
with the tough, flexible skin needed for a subterranean lifestyle has been 8 `( [+ q- M* i5 g# j9 y% V
identified as a key contributor to their cancer resistance. Hyaluronan, or
& } O: W) j4 \5 Y( \# ?hyaluronic acid, is a ubiquitous component of the extracellular matrix. Xiao ) }+ q! F; n& T
Tian et al. observed that the culture media of naked mole-rat
- r$ L) @3 V0 ]2 K1 S/ _$ S# Efibroblasts becomes viscous owing to the accumulation of a thick ‘gooey’
D" e: w+ f! B% Asubstance and identified it as a high-molecular-mass hyaluronan (HMM-HA), more 0 _$ A( q5 X8 ?: L8 ?2 s
than five times larger than mouse and human equivalents. It accumulates in naked $ ^! M, D. @( F7 C& {/ @
mole-rat tissues owing to low hyaluronidase activity and a unique form of , L2 s$ Z# D3 z8 S/ m
hyaluronan synthase 2. HMM-HA acts through the CD44 receptor and removal of b' a' }8 B6 J6 g
HMM-HA makes naked mole-rat cells more susceptible to transformation. This * A1 k8 P( u- D, i, ^
unusual model of cancer protection suggests potential new avenues of research 8 n; }- Q) H5 i2 r# s
into anticancer and life-extension strategies. Cover: Joel Sartore/National F/ v1 R) |# F# O/ V, m+ u6 Q( B8 U
Geographic Image Collection/Alamy5 Y6 [: Q. A1 Q6 A1 C/ W9 U: D
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总评分: 威望 + 20
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发表于 2013-7-19 19:33
发表于 2013-7-19 19:42
