|
- 积分
- 17983
- 威望
- 17983
- 包包
- 26159
|
1 V" }2 I b/ R2 `
) ~4 `5 y9 ` n# H: lNaked mole rats are remarkable in
0 U3 b& E r, B& S' G+ i2 O2 P, acombining extreme longevity with virtually complete resistance to cancer. Now a
6 g+ G" y! ^* Nnovel glycosaminoglycan variant that may have evolved to provide the creatures
, ~" ?% |8 c. m- H7 _$ l& k; _with the tough, flexible skin needed for a subterranean lifestyle has been 0 G& X) |! ~, n2 d9 p! G3 h$ ]
identified as a key contributor to their cancer resistance. Hyaluronan, or : F# V) @$ u. K
hyaluronic acid, is a ubiquitous component of the extracellular matrix. Xiao 3 j: ?% Z& D( ?# v' Z
Tian et al. observed that the culture media of naked mole-rat
+ Q. B' ]* T" _. f6 v: O1 l% }3 k% Nfibroblasts becomes viscous owing to the accumulation of a thick ‘gooey’ 1 z0 w( Z D$ _) s, U
substance and identified it as a high-molecular-mass hyaluronan (HMM-HA), more * V0 E0 m& \% C# S' Y$ f8 a
than five times larger than mouse and human equivalents. It accumulates in naked
, G' e- u8 z5 \1 Wmole-rat tissues owing to low hyaluronidase activity and a unique form of 5 F3 P; i- x3 R5 T9 r6 r) Y4 |
hyaluronan synthase 2. HMM-HA acts through the CD44 receptor and removal of
* @0 ^1 O. F5 V3 E5 `. WHMM-HA makes naked mole-rat cells more susceptible to transformation. This
* j7 A e) h$ Y2 @. junusual model of cancer protection suggests potential new avenues of research
& D5 ~7 r4 t$ R& Ginto anticancer and life-extension strategies. Cover: Joel Sartore/National
+ ^9 w# F. H) F, @/ |& c; `, RGeographic Image Collection/Alamy l- G1 {) \, h0 @: I
|
-
总评分: 威望 + 20
包包 + 20
查看全部评分
|
发表于 2013-7-19 19:33
