《科学》[Science]13年7月26日出版pdf全文

nero1981

2013-7-26 Science, d- U1 U4 D# p5 e! [) S* }9 Y
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COVER Immunostained fluorescence microscopy image of memory / w3 |7 i" m% t) L
engram–bearing cells (red) in the dentate gyrus of a mouse hippocampus (image % h& U# N, ^" a0 A
width: 1.5 millimeters). These cells were genetically tricked to express the , V( g4 F! j3 U
protein channelrhodopsin-2 during memory formation, thus becoming responsive to
/ I; U$ Z0 {0 B" j* Y4 olight stimulation. When the cells were activated by light, the mice % U6 v1 X+ O# r- [# T& P) C+ M
simultaneously associated a genuine memory with an undesirable event (a foot / K* m% C  j1 y) l" @9 Z
shock) to create a new but false memory. See page 387. Image: 3 ]  k$ d: v3 H' E2 A& U8 y
Xu Liu and Steve Ramirez
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