《科学》[Science]13年7月26日出版pdf全文

nero1981

2013-7-26 Science
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COVER Immunostained fluorescence microscopy image of memory 4 [/ R$ }, o- V/ w& y
engram–bearing cells (red) in the dentate gyrus of a mouse hippocampus (image
( i1 d, ]$ |, j# \- lwidth: 1.5 millimeters). These cells were genetically tricked to express the
6 t& ?- @3 O5 m$ ^protein channelrhodopsin-2 during memory formation, thus becoming responsive to 2 G' Q0 Y' ]/ _
light stimulation. When the cells were activated by light, the mice . F- y3 }! f6 d/ [2 _) _
simultaneously associated a genuine memory with an undesirable event (a foot
; p6 Z+ l( h1 l# ~shock) to create a new but false memory. See page 387. Image:
5 `& T' Q# d/ x# lXu Liu and Steve Ramirez
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