《科学》[Science]13年7月26日出版pdf全文

nero1981

2013-7-26 Science4 e" T- j, K6 l8 [
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COVER Immunostained fluorescence microscopy image of memory 4 Y; K- [' `! J* _6 Y
engram–bearing cells (red) in the dentate gyrus of a mouse hippocampus (image 5 i$ [6 C$ p2 z- v* H# L7 |
width: 1.5 millimeters). These cells were genetically tricked to express the
# a6 g- _  T* l' P, ?1 D  s+ R- iprotein channelrhodopsin-2 during memory formation, thus becoming responsive to + h# Y" v. c: d; ]
light stimulation. When the cells were activated by light, the mice ( W: ^* ]7 f0 b5 m3 q: B' p
simultaneously associated a genuine memory with an undesirable event (a foot
# k0 f  }7 D* `  L+ X5 j* }! Qshock) to create a new but false memory. See page 387. Image: . Y( }% A) r: v1 S" w; R& k
Xu Liu and Steve Ramirez
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