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2013-7-26 Science+ W5 e, z$ u$ h9 X* L( F0 l
- m$ w5 h2 w: ]1 u1 a0 UCOVER Immunostained fluorescence microscopy image of memory
F* q# H/ D5 V4 k `engram–bearing cells (red) in the dentate gyrus of a mouse hippocampus (image
' @6 r' U2 h+ o0 K" j2 k% q4 |width: 1.5 millimeters). These cells were genetically tricked to express the
& R. t1 f2 D, Uprotein channelrhodopsin-2 during memory formation, thus becoming responsive to 6 @, N" `9 H) ]+ I
light stimulation. When the cells were activated by light, the mice
0 @4 L6 Y. b H, R+ j# m( C: h& ]simultaneously associated a genuine memory with an undesirable event (a foot 9 z6 W: x- J6 \
shock) to create a new but false memory. See page 387. Image: $ R8 {7 t3 z: v# F$ j' C) P9 f
Xu Liu and Steve Ramirez * u4 o4 p1 B0 n2 ^
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发表于 2013-7-29 20:37
发表于 2013-7-29 22:42
