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jiays

Science. 1982 Oct 15;218(4569):297-8.. F4 U; Z- g, \; i5 R  H) A
An estrogen-binding protein and endogenous ligand in Saccharomyces cerevisiae: possible hormone receptor system.
, o) w; `' ^$ |7 c, T6 GFeldman D, Do Y, Burshell A, Stathis P, Loose DS.3 Q: G* a) K+ L1 b/ x. x4 ~
Abstract! D6 [, C8 ]0 k# P0 q" {
A protein macromolecule in the cytosol of the unicellular eukaryotic yeast Saccharomyces cerevisiae selectively binds the vertebrate estrogen hormone 17 beta-estradiol with high affinity. Lipid extracts of the yeast cells or the conditioned growth medium yield a substance that can bind competitively to the tritiated estradiol-binding sites in the yeast and to mammalian estrogen receptors. These findings suggest that the binding protein may be a primitive hormone receptor and that the lipid-extractable substance represents the endogenous ligand.
" T) q8 g& C/ D! P1 ?4 [8 n# v7 RPMID: 6289434 [PubMed - indexed for MEDLINE]
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网址：http://www.sciencemag.org/content/218/4569/297.long

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