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发表于 2014-4-18 09:33 |只看该作者 |倒序浏览 |打印
本帖最后由 jack1381818 于 2014-4-18 09:34 编辑 - l, l( w" g  S  f( A) j
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Cord Blood Registry is conducting a Phase 2 clinical trial at University of Texas Health Science Center to evaluate the safety and efficacy of delivering stem cells intravenously to cerebral palsy patients. The goal is to recruit 30 children with cerebral palsy, aged two to ten years, and administer either autologous cord blood stem cells (collected at the time of birth) or autologous bone marrow stem cells (collected from a bone marrow harvest). Five patients from either group will receive a placebo at baseline but will be given the option to receive stem cell treatment after one year. Follow-ups at 6, 12, and 24 months will be conducted at the University of Texas Health Medical School and Children’s Memorial Hermann Hospital.
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% P# J; u4 Y/ JDuring follow-ups, patients will be evaluated for treatment safety through pulmonary and hepatic function, neurological status, and hemorrhagic or ischemic lesions; they will be evaluated for treatment efficacy through MRI analysis of white matter tracts correlated with motor function studies. The study was initiated in November 2013 and is projected to end in November 2015. As of January 21, enrollment for the bone marrow harvest group was met.. y* ~2 t5 L$ x- y! L; d$ @

" p" n9 G; |0 o# FThis trial, like all trials, began in the laboratory. “There is preclinical data indicating that the ongoing neuroinflammatory response is a driver of further injury in cerebral palsy so the hope is to reduce this neuroinflammation,” stated Dr. Charles Cox, principal investigator of the study and a professor of Pediatric Surgery at UTHMS. The inflammation seen in cerebral palsy is caused by abnormal brain development and damage to the motor nervous system. It is thought that infusing a patient’s own stem cells may trigger repair mechanisms to alleviate the damage. “Our goal is to break the cycle of inflammation and injury,” said Dr. Cox in material from Cord Blood Registry. This goal is good news for the 1 in every 323 children in the United States who has been diagnosed with cerebral palsy, as the prevalence of the disease has increased over time.
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5 J/ s& q% d# u( r' l- `! aPosted by: Maureen Newman April 16, 2014
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沙发
发表于 2014-4-18 17:15 |只看该作者
基本上是说通过脐带血干细胞影响炎症反应的原理来治疗脑瘫病人的,而且已经进入一期临床研究了。但是以目前的结果来看,其实只是很不成熟的治疗方式,基本原理等都不清楚。因为脂肪干细胞,骨髓间充质干细胞都有抑制炎症反应的能力,但是都还缺乏可以临床应用的证据及疗效。不过任何治疗方式都是这样一步一步发展而来的,我相信干细胞研究确实是前途十分光明的。
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