|
- 积分
- 17983
- 威望
- 17983
- 包包
- 26159
|
本帖最后由 细胞海洋 于 2014-6-4 07:36 编辑 ( E# D- C6 j. I" V' @3 U
7 x% N+ K& V( d
2014年5月29日 Nature - i+ }. i( Y$ o8 j+ h) @
# z( s2 L3 X0 Q: @ \6 k8 vMore than a decade after publication of the draft human genome sequence, there is no direct equivalent for the human proteome. But in this issue of Nature two groups present mass spectrometry-based analysis of human tissues, body fluids and cells mapping the large majority of the human proteome. Akhilesh Pandey and colleagues identified 17,294 protein-coding genes and provide evidence of tissue- and cell-restricted proteins through expression profiling. They highlight the importance of proteogenomic analysis by identifying translated proteins from annotated pseudogenes, non-coding RNAs and untranslated regions. The data set is available on http://www.humanproteomemap.org. Bernhard Kuster and colleagues have assembled protein evidence for 18,097 genes in ProteomicsDB (available on https://www.proteomicsdb.org) and highlight the utility of the data, for example the identification of hundreds of translated lincRNAs, drug-sensitivity markers and discovering the quantitative relationship between mRNA and protein levels in tissues. Elsewhere in this issue, Vivien Marx reports on a third major proteomics project, the antibody-based Human Protein Atlas programme (http://www.proteinatlas.org/). Cover: Nik Spencer/Nature" F4 \: q0 z$ S6 l) o* ^- r
2 U" j& s3 Z2 H+ O: E, W
/ b; x" {4 s3 @' l- U5 H V l' U |
-
总评分: 威望 + 20
包包 + 20
查看全部评分
|
发表于 2014-6-3 22:29
