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本帖最后由 细胞海洋 于 2014-6-4 07:36 编辑 0 Y: T1 L' m: U! d7 @, I8 C/ w( o4 v
6 X" G/ j! _" A' |# `- Z% i2014年5月29日 Nature
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; i: b; U: q5 \1 d3 \# lMore than a decade after publication of the draft human genome sequence, there is no direct equivalent for the human proteome. But in this issue of Nature two groups present mass spectrometry-based analysis of human tissues, body fluids and cells mapping the large majority of the human proteome. Akhilesh Pandey and colleagues identified 17,294 protein-coding genes and provide evidence of tissue- and cell-restricted proteins through expression profiling. They highlight the importance of proteogenomic analysis by identifying translated proteins from annotated pseudogenes, non-coding RNAs and untranslated regions. The data set is available on http://www.humanproteomemap.org. Bernhard Kuster and colleagues have assembled protein evidence for 18,097 genes in ProteomicsDB (available on https://www.proteomicsdb.org) and highlight the utility of the data, for example the identification of hundreds of translated lincRNAs, drug-sensitivity markers and discovering the quantitative relationship between mRNA and protein levels in tissues. Elsewhere in this issue, Vivien Marx reports on a third major proteomics project, the antibody-based Human Protein Atlas programme (http://www.proteinatlas.org/). Cover: Nik Spencer/Nature$ H4 ]4 X$ Z- o7 V, |
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发表于 2014-6-3 22:29
