求助干细胞治疗多发性硬化文献一篇，急！

mantianfeiyun

各位大侠，紧急求助一篇文献，非常感谢！具体信息如下：! ~6 C' j# Y( p$ u2 Q( c7 p

, v; H2 v/ [# y% w: u* y  g5 g6 l1. Cell Transplant. 2014 Nov 5. [Epub ahead of print]9 p( }8 u% L$ ~$ j
% [/ [$ Z* _- o* i/ M. p; J2 B
The potential of human umbilical cord-derived mesenchymal stem cells as a novel2 s9 g  K! K9 n: t
cellular therapy for multiple sclerosis.2 \$ l6 {  T( u5 r- j; `" z* r

' G  u+ f/ F5 d" a7 R  Y1 b  [Li JF, Zhang DJ, Geng T, Chen L, Huang H, Yin HL, Zhang YZ, Lou JY, Cao B, Wang
' [. o. g9 G3 q9 H/ _YL.0 G4 u+ l# F6 c" `- P9 s/ P0 j

- }: d" r+ d; [: R/ O2 W4 xMultiple sclerosis (MS) is a complex disease of neurological disability,
, i9 C0 A: `) \! [/ m% k; Yaffecting more than 300 out of every one million people in the world. The purpose
+ V: J! V) d, s+ }of the study was to evaluate the therapeutic effects of human umbilical
5 R' g  [* O2 d$ b% ?cord-derived mesenchymal stem cell (hUC-MSC) transplantation in MS patients.
) A8 n8 l% N9 O2 h, `  ]9 x$ GTwenty-three patients were enrolled in this study and 13 of them were given
+ M  S$ W# m! i0 J& u0 thUC-MSC therapy at the same time as anti-inflammatory treatment, whereas the& L2 P$ D- D# H1 m- [: Y+ V
control patients received the anti-inflammatory treatment only. Treatment% X) y. l9 n2 @7 v( J
schedule included 1,000 mg/kg of methylprednisolone i.v. daily for 3 days and
3 i& |! a- z8 Jthen 500 mg/kg for 2 days, followed by oral prednisone 1mg/kg/day for 10 days.
( }0 T: p0 `1 x- Z! o8 G1 _% B# Q5 cThe dosage of prednisone was then reduced by 5mg every two weeks until reaching a
' o, U$ H& |! I  q5mg/day maintenance dosage. Intravenous infusion of hUC-MSCs was applied three
  Q# L3 p! w. g3 U1 a! Ftimes in a 6 week period for each patient. The overall symptoms of the hUC-MSC4 E3 ~6 n3 @. x9 a. E& X
treated patients improved compared to patients in the control group. Both the% h: @; k# l& P' b( k1 R" V4 h
EDSS scores and relapse occurrence were significantly lower than those of the1 s- C4 r5 t' L8 D
control patients. Inflammatory cytokines were assessed, and the data demonstrated+ {  U/ P( V! g. X
a shift from Th1 to Th2 immunity in hUC-MSC treated patients. Our data2 r9 w4 v( F- Y( k- D9 H( P
demonstrated a high potential for hUC-MSC treatment of MS. This manuscript is9 R3 I# V* e. L% h
published as part of the International Association of Neurorestoratology (IANR)5 ~$ k8 N( H; W4 ]( B
special issue of Cell Transplantation.
0 h9 s7 t+ B! m+ Z/ c/ C
. f) Q7 |) C& a. Y* sPMID: 25385295  [PubMed - as supplied by publisher]
- V* o+ R9 A) H3 C9 ]
2 j) ]) e% y4 W! l% p4 ^8 U# n再次感谢！\(^o^)/~

benben52150

mantianfeiyun 发表于 2014-12-3 09:17 + b$ x5 t8 \2 W2 b  ]
回复 benben52150 的帖子
" }4 |( J& w4 q! Z* r' A# p8 n+ c
不好意思，看错了，是我需要的文献，多谢多谢啊！

: Q% @% Y$ r# l1 q! |
客气

mantianfeiyun

回复 benben52150 的帖子
( I  B( j3 m  @
2 b3 J, g9 r& z2 }7 }+ R2 ^* i. X9 c不好意思，看错了，是我需要的文献，多谢多谢啊！

mantianfeiyun

回复 benben52150 的帖子' [1 N- ^+ c. V" A3 ~) p4 O

( A8 \8 j) y% s; R/ I. V/ Q0 B呵呵老兄，多谢热心帮助啊！但你提供的文献不是我想要的哦！
- U* g( H3 h# e, H! J# k
+ }( J  c# \, \0 h% q) M+ m我要的文章是2014.11新发的，Cell Transplant的，而你提供的文献是2011年发表于Stem Cell Rev and Rep的
  V1 f& l( N2 f5 N# t# n  O" z/ o
不知能否继续帮我找2014年的这篇文献？再次感谢！

benben52150

你需要的。。