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本帖最后由 细胞海洋 于 2013-6-14 09:50 编辑 8 I5 E, |* o, | O
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Y Ruzankina1 and EJ Brown*,1& K- S: q. ]; E" a s9 U6 `; o
1Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Blvd., Philadelphia,
1 _" z& m0 ~; J( \& fPA 19104-6160, USA1 N5 v" v0 d" P$ G/ ^1 ]
Ageing is a complex process characterised by a variety of disorders associated with general organismal decline and an inability to6 D6 B+ x, |6 I0 V& R) |( D
maintain tissue homoeostasis. As described in this review, recent studies indicate that ageing may be caused, in part, by the depletion. `# V/ y) p' ~; l( C; [, q, t- y
of stem and progenitor cells that govern tissue renewal. The potential causes of stem and progenitor cell attrition are numerous;0 g8 @/ s }( L3 i
however, a commonly accepted theory is that these cells are lost as a result of naturally occurring DNA damage and the obligate
5 p+ x) E5 }4 {2 Bcheckpoint responses that follow. Failure to launch appropriate responses to DNA damage is strongly associated with cancer
$ h* N: e; y8 \; Iinitiation and progression. Therefore, it is at this nexus, the response to DNA damage, that an important organismal fate may be
" I9 ?1 N) N6 \9 c- K4 o5 Tdetermined: to degrade regenerative potential for the purpose of preventing cancer. According to this viewpoint, ageing may be the, h1 j4 k6 c; L/ R$ ^4 I. _
unfortunate mark of successful cancer suppression in stem cells and other cell types. In this review, we will describe how degeneration
* u5 x% E3 W5 h* ?' kof tissue renewal capacity links ageing and cancer suppression.7 q* a, \' X5 x! W S- L/ _; E
British Journal of Cancer (2007) 97, 1189–1193. doi:10.1038/sj.bjc.6604029 www.bjcancer.com9 J9 z2 x0 O$ X* f0 v4 z! Y N
Published online 9 October 2007% h) V% F7 T+ |! O0 A
& 2007 Cancer Research UK6 _7 r9 ]8 X6 u; q. Z
Keywords: ageing; stem cells; DNA damage; oncogenes
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4 d8 h: y! }. j7 ]: I附件为pdf全文，回复本贴可以下载，感谢对本版主的支持
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Relationships between stem cell exhaustion, tumour suppression and ageing.pdf
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发表于 2009-3-25 09:19
发表于 2009-4-28 09:17
