|
  
- 积分
- 97
- 威望
- 97
- 包包
- 3142
|
本帖最后由 细胞海洋 于 2013-6-14 09:50 编辑 . ]9 E+ k4 w2 V) w
. t/ w, X. W0 M+ `2 s8 j1 }
Y Ruzankina1 and EJ Brown*,1
1 u+ |( F6 R6 z* ~1Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Blvd., Philadelphia,( }0 r& {+ @" x* y) l
PA 19104-6160, USA
* L3 `, N3 l! x' S8 CAgeing is a complex process characterised by a variety of disorders associated with general organismal decline and an inability to
; a& m. A. I A" D5 Dmaintain tissue homoeostasis. As described in this review, recent studies indicate that ageing may be caused, in part, by the depletion
6 I8 U$ J/ }, w0 B( p0 l1 ^of stem and progenitor cells that govern tissue renewal. The potential causes of stem and progenitor cell attrition are numerous;4 J X" `% H3 r* h# R
however, a commonly accepted theory is that these cells are lost as a result of naturally occurring DNA damage and the obligate( K9 [$ J) V5 ]5 ?; u
checkpoint responses that follow. Failure to launch appropriate responses to DNA damage is strongly associated with cancer
1 u: L* [. ]8 D. B' `% e$ cinitiation and progression. Therefore, it is at this nexus, the response to DNA damage, that an important organismal fate may be
3 h' ~4 _! Z- R3 T% {1 Gdetermined: to degrade regenerative potential for the purpose of preventing cancer. According to this viewpoint, ageing may be the
6 ^1 A7 u4 X, e: x% b3 ^% j" b* |2 ^unfortunate mark of successful cancer suppression in stem cells and other cell types. In this review, we will describe how degeneration* v3 W; W. `# e g$ R5 n
of tissue renewal capacity links ageing and cancer suppression.
w7 h' _$ I2 @# XBritish Journal of Cancer (2007) 97, 1189–1193. doi:10.1038/sj.bjc.6604029 www.bjcancer.com5 n( _3 B! ]8 u. S% j7 J1 h+ E
Published online 9 October 2007- T; p' j. g( K( N$ p$ L
& 2007 Cancer Research UK6 Y) m8 } I# B2 ^" K# E
Keywords: ageing; stem cells; DNA damage; oncogenes
" r2 c+ f9 L0 p" S
8 ]. M4 K" S. H* z# G附件为pdf全文，回复本贴可以下载，感谢对本版主的支持4 z/ Q# j M3 |- c4 F/ O
8 z) A7 ?& ^. |
Relationships between stem cell exhaustion, tumour suppression and ageing.pdf
(163.02 KB)
|
|
发表于 2009-3-25 09:19
发表于 2009-4-28 09:17
