讨论：胰腺癌细胞重编程为正常细胞的机理是什么？

helong

Pancreatic ductal adenocarcinoma (PDA) cells retain a high degree of plasticity, which can be exploited to induce a quiescent acinar cell state with reduced tumorigenic potential. 孙学军翻译的不对，不是把胰腺癌细胞转化为正常细胞，而是成瘤性降低的静息状态，因此意义没有这么显著；重编程的机理，文章说了：by shifting key transcription programs：背景是Kras mutation导致lose signaling from basichelix-loop-helix (bHLH) transcription factors.