Scientists replace teeth

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日期: 2004-05-04 今日/总浏览: 1/7563 O* n- e% m' O  y# m7 O
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8 {+ E" g( S+ ZSuccessfultestsonmiceshowthetechnologymayletpeoplegrowtheirownreplacementteeth.8 u, u& p6 q) o4 n
TheLondonteamatKingsCollegehavebeenawarded£500,000($887,500)tofurthertheirresearchandhavesetupaprivatecompany,Odontis,todeveloptheirplans.: C7 A( a8 m6 A% A
Thescientistssaythetechnologywillallowthosewithmissingteethtofillthegapsintheirmouthwithouthavingtoresorttofalseteeth,bridgesorsyntheticimplants.& w+ ]* p; |9 i  h! q9 E
Thetechnologyworksbytakingstemcells--mastercellsthatcanbeprogrammedtomakedifferentkindsoftissue--fromthepatientwhicharetreatedandculturedinthelab.1 ~1 _# `1 z0 B! C: l) L/ P* }9 c- L
Theyarethenre-implantedinthepatient’sjawunderthegumwherethetoothismissing.
5 Z' c- a9 Z% K! ?; `$ QProf.PaulSharpe,thegeneticresearchscientistbehindthetechnique,toldtheUK’sPressAssociationthatitwashopedthetoothwouldthengrowintoafully-formed,livetoothinaroundtwomonths./ [3 u' k9 P( C% ~
Hesaidthetechniquehadbeentestedinmiceandtheyhopedtomoveontotrialsinhumansinthenexttwoyears.
8 s3 w6 p: w: q4 Q" t' K3 d! d, sButitcouldbefiveyearsbeforethetechnologyiswidelyavailabletothegeneralpublic.: Q) n9 e3 Q) b0 w
Theresearchersaretestingthesuccessofstemcellstakingfromdifferentpartsofthebody,suchasfrombonemarroworteeththemselves.5 }+ Z, A5 J, `: J
Prof.Sharpe,headofdivisionofCraniofacialBiologyandBiomaterialsattheDentalInstituteatKing’sCollege,saidthecostshouldnotbemorethanthecurrentpricetagforsyntheticimplants--around£1,500($2,660)--£2,000($3,550).
9 A2 V8 f0 u0 N3 {7 ^8 A3 rAkeyadvantageofourtechnologyisthatalivingtoothcanpreservethehealthofthesurroundingtissuesmuchbetterthanartificialprosthesis,hetoldPA.
- D# k& x8 s2 I( }. r( FTeethareliving,andtheyareabletorespondtoaperson’sbite.* ?/ E# |  g8 w! B3 Q
Theymoveandindoingsotheymaintainthehealthofthesurroundinggumsandteeth,hesaid.
4 s- a9 L+ i/ uIntheUKandU.S.,peopleovertheageof50loseanaverageof12teethfromafullsetof32.3 o4 L5 C7 b# \' S) _
Problemsassociatedwithlossofteethincludegeneralhealth,nutritionandphysicalappearance.# f- Q5 y- x9 g0 z& C, o1 _7 o
Prof.Sharpe’sprojecthasbeenawarded£300,000($532,500)fromtheWellcomeTrust,£100,000($177,500)fromtheNationalEndowmentforScience,TechnologyandtheArts(NESTA)and£100,000fromabusinesssponsor.6 Q9 S& u' M* C! L. Y7 b; u# {
MarkWhite,inventionandinnovationdirectoratNESTA,toldPA:Odontishavecomeupwithadentalmethodthatishighlyinnovativeandpioneeringinitsapproach.
. W5 g: }5 ]* c8 oWehopethatourseedinvestmentwillbringaboutamajorsuccessstoryfortheUKresearchandsciencecommunity.
& L1 T, W" R6 n% [! o  DAspokesmanfortheBritishDentalAssociation(BDA)toldPA:TheBDAwelcomesprojectslikeOdontisandlooksforwardtoseeingfurtherprogressinthisfield.
: [8 M/ i+ W9 x: L* g0 A3 }9 W; T( BTheBDAisalsopleasedtoseethelevelofinvestmentforthisprojectfromNESTAandhopesthatfutureoralhealthprojectswillbegivensimilarpriority.! b( }9 P+ ]" q
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http://www.odontis.co.uk/
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Faketeeth,dentureglueandsuckingonbaldgumsmaysoonbecomeathingofthepast,sayagroupofBritishscientistsworkingonaprocedurethatmakesteethgrowfromstemcellsimplantedinthegum.
  Q/ t1 I+ R% M0 I* bThescientistsatKing’sCollege,LondonannouncedMondaytheyhadmadeabreakthroughinmice,coaxingstemcellstogrowintoteethwithinonlyafewweeks.
8 Z  d: A, [& T1 ^Theprocedureentailstakingstemcellsfromalivingbeing,nurturingtheminalaboratoryuntiltheyformaballofnewcellsknownasabud,andinsertingthebudintothegumwherethenewtoothisneeded.5 f5 }5 R* s* x/ q- u1 J
Theresearchersestimatehumanteethinadultscouldtakeabouttwomonthstodevelopfully.+ J& f) x* [  ~3 {5 |
Stemcellsareundifferentiatedcellsthathavethepotentialtogrowintootherkindsofcellsinthebody,andareoftenusedinbiologicalresearch.
$ h  d. M, ~: [* V3 O! i  e5 bThecollegehassetupaprivatecompany,Odontis,todeveloptheventure,andwasgivenastart-upgrantof500,000pounds(750,000euros,895,000dollars)toworktowardacommercialproductforhumans,theBBCreported.+ {# p' r4 r! \+ G, A- i
Testingonhumanscouldbegininabouttwoyears.4 v5 h' G4 @1 X1 u7 I
Thereisnoreasonwhyitshouldn’tworkinhumans,theprinciplesarethesame,PaulSharpe,aspecialistinthefieldofregenerativedentistryandthedeveloperofthetechnique,toldtheGuardiannewspaper." b' I2 n1 w1 _# G3 f
Ifprovensuccessful,theprocedurecouldbeaboonforBritain,wherepeopleover50loseonaverage12oftheir32teeth.6 f* _2 C9 F8 L# i
Sharpesaystheprocedurecouldhaveadvantagesoverfalseteeththatrequireametalposttobedrivenintothejaw.7 y7 [7 f7 A' z6 `* S
Thatsurgerycanbeextensiveandyouneedtohavegoodsolidboneinthejawandthat’samajorproblemforsomepeople,saidSharpe.
7 ^4 r7 e7 ?8 }Thenewmethodcouldbeusedonfarmorepatientsbecausetheballofcellsthatgrowsintoatoothalsoproducesbonethatanchorstothejaw.  x  K7 E6 s, v
Inwhatisexpectedtobeasimpleprocedure,thenewmethodwillrequireonlyalocalanaesthetic.
1 q% A. s1 H" `$ j8 jThecostofgrowingarealtoothshouldalsobenomorethanthatofasyntheticimplant,between1,500and2,000pounds(2,226-2,969euros,2,657-3,544dollars).6 z" |; t# V( U  X. j9 G
Butgap-toothedBritonswillhavetowaittofilltheirsmile.1 _' a. ?! w5 `  u
Theoptimisticscientistssaytheyhopetomakethetechnologyavailabletothegeneralpublicwithinfiveyears.
! J' m& @+ @( e% X" w3 }3 dAkeyadvantageofourtechnologyisthatalivingtoothcanpreservethehealthofthesurroundingtissuesmuchbetterthananartificialprosthesis,SharpetoldtheBBC.
+ `. C8 m( V6 xTeethareliving,andtheyareabletorespondtoaperson’sbite.! ^8 E5 S7 Y6 m5 f
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2 [# V) Y3 A. w来源: CNN
$ {/ o/ x" ~, L: i) T1 V) H3 b发布者: 刘斌