Scientists replace teeth

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日期: 2004-05-04 今日/总浏览: 1/756( t: z) L; {* ^1 }! t0 r  _0 K) P
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Successfultestsonmiceshowthetechnologymayletpeoplegrowtheirownreplacementteeth.# h+ R' k+ ], X$ z7 T
TheLondonteamatKingsCollegehavebeenawarded£500,000($887,500)tofurthertheirresearchandhavesetupaprivatecompany,Odontis,todeveloptheirplans./ i8 H+ h5 n$ J  b+ r6 d  _
Thescientistssaythetechnologywillallowthosewithmissingteethtofillthegapsintheirmouthwithouthavingtoresorttofalseteeth,bridgesorsyntheticimplants.
& N) B8 Q, F0 L/ U& qThetechnologyworksbytakingstemcells--mastercellsthatcanbeprogrammedtomakedifferentkindsoftissue--fromthepatientwhicharetreatedandculturedinthelab.
& S# b9 F( O& t. a5 r/ ~5 QTheyarethenre-implantedinthepatient’sjawunderthegumwherethetoothismissing.
3 R% p2 l* B8 C5 f4 w: Q" W9 oProf.PaulSharpe,thegeneticresearchscientistbehindthetechnique,toldtheUK’sPressAssociationthatitwashopedthetoothwouldthengrowintoafully-formed,livetoothinaroundtwomonths.. _" r5 S$ x) C
Hesaidthetechniquehadbeentestedinmiceandtheyhopedtomoveontotrialsinhumansinthenexttwoyears.
+ `4 D7 N1 s$ f$ h9 RButitcouldbefiveyearsbeforethetechnologyiswidelyavailabletothegeneralpublic.
2 Y$ H$ O) V! h$ N! [* t; X2 ^! B  MTheresearchersaretestingthesuccessofstemcellstakingfromdifferentpartsofthebody,suchasfrombonemarroworteeththemselves.' M; B6 b) d6 l) w5 q+ }' ~  S
Prof.Sharpe,headofdivisionofCraniofacialBiologyandBiomaterialsattheDentalInstituteatKing’sCollege,saidthecostshouldnotbemorethanthecurrentpricetagforsyntheticimplants--around£1,500($2,660)--£2,000($3,550).
- s* G( n; |5 J% {  lAkeyadvantageofourtechnologyisthatalivingtoothcanpreservethehealthofthesurroundingtissuesmuchbetterthanartificialprosthesis,hetoldPA.0 N& n* N( S0 y) ]  ~) _: ?, ?
Teethareliving,andtheyareabletorespondtoaperson’sbite.
1 m/ j* \+ T, a/ n# O- ]$ G: KTheymoveandindoingsotheymaintainthehealthofthesurroundinggumsandteeth,hesaid.
( @; ~% W0 \! ^3 _, w. j/ uIntheUKandU.S.,peopleovertheageof50loseanaverageof12teethfromafullsetof32.: W, Y' l* k( ?( c# W3 E: T
Problemsassociatedwithlossofteethincludegeneralhealth,nutritionandphysicalappearance.
8 T. z5 B: i. \7 WProf.Sharpe’sprojecthasbeenawarded£300,000($532,500)fromtheWellcomeTrust,£100,000($177,500)fromtheNationalEndowmentforScience,TechnologyandtheArts(NESTA)and£100,000fromabusinesssponsor.% i2 O" b  a# a% [* @% m& Y
MarkWhite,inventionandinnovationdirectoratNESTA,toldPA:Odontishavecomeupwithadentalmethodthatishighlyinnovativeandpioneeringinitsapproach.) b' [6 \3 J9 n
WehopethatourseedinvestmentwillbringaboutamajorsuccessstoryfortheUKresearchandsciencecommunity.9 Y6 C4 k8 L3 A* R# q  I
AspokesmanfortheBritishDentalAssociation(BDA)toldPA:TheBDAwelcomesprojectslikeOdontisandlooksforwardtoseeingfurtherprogressinthisfield.
0 Y9 a" l  n2 C4 q+ UTheBDAisalsopleasedtoseethelevelofinvestmentforthisprojectfromNESTAandhopesthatfutureoralhealthprojectswillbegivensimilarpriority.
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- u- J7 K& V6 U/ ^http://www.odontis.co.uk/
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$ S# c/ r' _( J& |Faketeeth,dentureglueandsuckingonbaldgumsmaysoonbecomeathingofthepast,sayagroupofBritishscientistsworkingonaprocedurethatmakesteethgrowfromstemcellsimplantedinthegum.: {" j0 K1 B' M) N- I, w: R! e
ThescientistsatKing’sCollege,LondonannouncedMondaytheyhadmadeabreakthroughinmice,coaxingstemcellstogrowintoteethwithinonlyafewweeks.
5 G5 x: {- t. X3 _8 ZTheprocedureentailstakingstemcellsfromalivingbeing,nurturingtheminalaboratoryuntiltheyformaballofnewcellsknownasabud,andinsertingthebudintothegumwherethenewtoothisneeded.1 _* e- e+ u/ M' V2 Q
Theresearchersestimatehumanteethinadultscouldtakeabouttwomonthstodevelopfully.# q2 X0 d/ Z! Z$ Y; Y
Stemcellsareundifferentiatedcellsthathavethepotentialtogrowintootherkindsofcellsinthebody,andareoftenusedinbiologicalresearch.
2 ^" B8 f7 }3 u- \& ^) O: \' eThecollegehassetupaprivatecompany,Odontis,todeveloptheventure,andwasgivenastart-upgrantof500,000pounds(750,000euros,895,000dollars)toworktowardacommercialproductforhumans,theBBCreported.
$ f/ @4 V, _3 E8 k2 l# q" bTestingonhumanscouldbegininabouttwoyears.
3 }$ X, b# Y. K. _" g/ e! d) SThereisnoreasonwhyitshouldn’tworkinhumans,theprinciplesarethesame,PaulSharpe,aspecialistinthefieldofregenerativedentistryandthedeveloperofthetechnique,toldtheGuardiannewspaper.
9 m3 ^+ ?- [2 W8 A# _* L1 z: IIfprovensuccessful,theprocedurecouldbeaboonforBritain,wherepeopleover50loseonaverage12oftheir32teeth.' A& Y; T( C$ `; X
Sharpesaystheprocedurecouldhaveadvantagesoverfalseteeththatrequireametalposttobedrivenintothejaw./ D$ n. B; r6 ]; R: @
Thatsurgerycanbeextensiveandyouneedtohavegoodsolidboneinthejawandthat’samajorproblemforsomepeople,saidSharpe.  c$ e2 n0 @2 U7 k" j
Thenewmethodcouldbeusedonfarmorepatientsbecausetheballofcellsthatgrowsintoatoothalsoproducesbonethatanchorstothejaw.7 r* _$ o; I& N( X
Inwhatisexpectedtobeasimpleprocedure,thenewmethodwillrequireonlyalocalanaesthetic.
4 I' R! q) U5 t! xThecostofgrowingarealtoothshouldalsobenomorethanthatofasyntheticimplant,between1,500and2,000pounds(2,226-2,969euros,2,657-3,544dollars).# U8 S3 b$ v7 j% O8 V: s7 ?4 A! h
Butgap-toothedBritonswillhavetowaittofilltheirsmile." o5 B, a6 t1 `+ y
Theoptimisticscientistssaytheyhopetomakethetechnologyavailabletothegeneralpublicwithinfiveyears.. ^4 A* E/ o$ F0 |' d2 h) s: I8 N
Akeyadvantageofourtechnologyisthatalivingtoothcanpreservethehealthofthesurroundingtissuesmuchbetterthananartificialprosthesis,SharpetoldtheBBC.
& l, R( I# d& _" ]+ h8 @4 c6 t3 RTeethareliving,andtheyareabletorespondtoaperson’sbite.
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2 K5 k* t+ @+ `' V& t& d2 V作者: ! T6 w/ B, U# {( U
来源: CNN# C# L8 k, D& \" e
发布者: 刘斌