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Cancer Res. 2013 Aug 2. [Epub ahead of print]. V9 M* |6 ]( @! D9 j7 z6 L$ X
p63, Sharp1, and HIFs: Master Regulators of Metastasis in Triple-Negative Breast Cancer.
& Q0 K- V6 ]* M/ X  z$ l  cPiccolo S, Enzo E, Montagner M.
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+ w" _. U) ]! p- a7 t/ J" s5 v& x. z, G7 HAuthors' Affiliation: Department of Molecular Medicine, School of Medicine, University of Padua, Padua, Italy.
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; w+ e6 n( x2 `Abstract
- ~& \" D% {2 ~5 f, [: ^Metastasis is the most significant cause of cancer-associated morbidity and mortality but remains poorly understood. Recent work revealed that metastasis of aggressive triple-negative breast cancers is suppressed by Sharp1, a factor that promotes degradation of hypoxia-inducible factors (HIF) and blunts HIF-induced malignant cell behavior. Cancer Res; 73(16); 1-4. ©2013 AACR.
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/ j' S# n& B; G! dPMID: 23913939 [PubMed - as supplied by publisher]2 N3 j1 S" n% W( d% t
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