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Cancer Res. 2013 Aug 2. [Epub ahead of print]6 S4 q+ {6 T d6 C# L
p63, Sharp1, and HIFs: Master Regulators of Metastasis in Triple-Negative Breast Cancer.
) S9 ~" S: H& J) VPiccolo S, Enzo E, Montagner M.
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Authors' Affiliation: Department of Molecular Medicine, School of Medicine, University of Padua, Padua, Italy.
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Abstract
* |1 h6 k! Z: k6 ^Metastasis is the most significant cause of cancer-associated morbidity and mortality but remains poorly understood. Recent work revealed that metastasis of aggressive triple-negative breast cancers is suppressed by Sharp1, a factor that promotes degradation of hypoxia-inducible factors (HIF) and blunts HIF-induced malignant cell behavior. Cancer Res; 73(16); 1-4. ©2013 AACR.5 x( J6 @$ ^" s0 ^. @' S
) f. U, R; T- X. P, |; ^6 H: zPMID: 23913939 [PubMed - as supplied by publisher]
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发表于 2013-8-8 23:25
