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Cancer Res. 2013 Aug 2. [Epub ahead of print]
' f" | W% h2 c/ \p63, Sharp1, and HIFs: Master Regulators of Metastasis in Triple-Negative Breast Cancer.) v2 M; ]- \9 P* |$ f
Piccolo S, Enzo E, Montagner M.
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Authors' Affiliation: Department of Molecular Medicine, School of Medicine, University of Padua, Padua, Italy.0 O0 u( B- J, {; q1 O" J) r
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Abstract
% }9 g3 v% n4 i( @6 IMetastasis is the most significant cause of cancer-associated morbidity and mortality but remains poorly understood. Recent work revealed that metastasis of aggressive triple-negative breast cancers is suppressed by Sharp1, a factor that promotes degradation of hypoxia-inducible factors (HIF) and blunts HIF-induced malignant cell behavior. Cancer Res; 73(16); 1-4. ©2013 AACR.
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PMID: 23913939 [PubMed - as supplied by publisher]5 e+ J4 A0 f. k$ W* _
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