PPT:Themes in B cell development (UCSF)

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Anthony DeFranco
/ S8 J! m5 R& Y! K7 s  HDepartment of Microbiology & Immunology, University of California at San Francisco2 j% y9 `, \6 q" a

1 Z! F7 V( r4 E4 N, `Themes include:
# [) A5 M: |$ x) v1. Checkpoints in B cell development:  feedback from Ig gene rearrangements; V- |, l9 J* @5 i  A5 B
2. Stromal environment/growth factors for B cell development. i: w7 U; U1 ]
3. Lineage commitment:  transcription factors and Notch signaling' K( j& R/ G  l( k9 }0 I
4. Central tolerance of B cells
4 P: k0 l* j( r8 @/ H6 u5. Peripheral tolerance of B cells1 W- @  g* v% r% v$ a' Z
6. 3 different types of mature B cells: choice of cell fate and relative roles