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本帖最后由 aspen 于 2009-8-31 09:53 编辑 1 e! p- T( _" T+ }1 N4 f
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Anthony DeFranco
0 g# Q1 G! r9 i4 m, R$ c" X. aDepartment of Microbiology & Immunology, University of California at San Francisco
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) |2 ^; \" I9 LThemes include:1 N" d% S6 O" |% ^! u. X; n/ _
1. Checkpoints in B cell development: feedback from Ig gene rearrangements; c6 P/ D$ ?1 Q
2. Stromal environment/growth factors for B cell development
! X1 c' y) T5 P$ ]3. Lineage commitment: transcription factors and Notch signaling8 F* p+ L) }0 O5 \. K$ B
4. Central tolerance of B cells3 D1 h) n+ i; `9 _6 o: Y* ^
5. Peripheral tolerance of B cells# j1 U+ k- b+ v. b( G) D
6. 3 different types of mature B cells: choice of cell fate and relative roles |
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