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Liver cirrhosis (LC) is the end stage of chronic liver disease and
- l5 F) A% |) M. w. @5 qis very difficult to treat. Currently, liver transplantation is one of
& o& _; }7 h# ^8 ?8 {! ethe only effective therapies available to such patients. However,
& q% n6 D$ t; S, W# a2 J4 gserious problems are associated with liver transplantation: lack; f" P" J, F/ {- c1 s6 ]
of donors, surgical complications, rejection, and high cost. Regenerative
+ r! Y$ O; t5 E/ ~/ L& v9 }therapies have the potential to provide minimally
+ l3 _5 Z& B; S4 ^, xinvasive procedures with few complications.
2 R+ f5 x# ?2 a) j8 yThe potential for stem cells in bone marrow (BM) to differentiate4 L9 ]) V! \- ~0 L
into hepatocytes and intestinal cells was recently confirmed" I5 a. ~; B. T6 J
through detection of Y chromosome-containing cells in
- [" t7 ^; M/ d- \samples from female recipients of BM cells (BMCs) from male
. |9 `7 a9 S; L' u7 rdonors [1–3]. BMC transplantation has been performed to treat
$ |& u$ ~" B- X0 t j) X$ Nhematological diseases, and several clinical studies have applied
U' E6 H7 a- W6 }/ _BMC injection to induce regeneration of myocardium and blood8 n" [1 U# A# {8 g7 I& _# K
vessels [4]. Taken together, these findings suggest that BMCs# `6 u$ a) U: s X3 O4 P
are effective sources for regenerative liver therapy. |
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发表于 2010-6-21 19:07
