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Liver cirrhosis (LC) is the end stage of chronic liver disease and
" \. k& Z' T# N/ w+ g8 Q9 Uis very difficult to treat. Currently, liver transplantation is one of
" K) O' {* f1 `" c- K5 F! W/ N& \* }the only effective therapies available to such patients. However,
4 @! I! x; l8 o2 T( eserious problems are associated with liver transplantation: lack
9 H0 L& T& `. B; l3 |+ cof donors, surgical complications, rejection, and high cost. Regenerative
$ `5 u) C0 p9 k+ L) ctherapies have the potential to provide minimally0 k j0 o1 m; ^5 k7 p1 p
invasive procedures with few complications.
; p9 a0 S3 @8 U0 S5 nThe potential for stem cells in bone marrow (BM) to differentiate
, `$ C0 d* t+ vinto hepatocytes and intestinal cells was recently confirmed
, C# F3 }# h1 Q0 z( Cthrough detection of Y chromosome-containing cells in
2 _( G# t& \, r; P" f2 z9 ]5 }samples from female recipients of BM cells (BMCs) from male
: f2 k3 C5 w* T4 h+ X: Ddonors [1–3]. BMC transplantation has been performed to treat
3 C" H) M: x2 Y* shematological diseases, and several clinical studies have applied( ~9 {& M2 G) g# p% B7 B- c' v
BMC injection to induce regeneration of myocardium and blood; G/ L, U, h: T- d$ R4 S
vessels [4]. Taken together, these findings suggest that BMCs
8 \9 N# p' |' B+ {( @; Z0 v5 ~: Z. Fare effective sources for regenerative liver therapy. |
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发表于 2010-6-21 19:07
