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Liver cirrhosis (LC) is the end stage of chronic liver disease and& D# y" `& n$ t, ~4 ]
is very difficult to treat. Currently, liver transplantation is one of
4 M ^+ W: a; fthe only effective therapies available to such patients. However,/ B* ?: N& O7 Q
serious problems are associated with liver transplantation: lack
& _1 {; U' v6 g6 ?2 c, Xof donors, surgical complications, rejection, and high cost. Regenerative
9 @7 X3 w/ B, w7 B! Itherapies have the potential to provide minimally
! \3 L1 Q. @5 B4 K9 ^3 w1 D/ n/ R" {" Einvasive procedures with few complications.% _4 x/ J4 D' Q( L4 w0 @
The potential for stem cells in bone marrow (BM) to differentiate
- o) t& u/ k( R, E. pinto hepatocytes and intestinal cells was recently confirmed5 [( } T+ X) i9 x7 E
through detection of Y chromosome-containing cells in1 t+ ^8 l' r0 x- L
samples from female recipients of BM cells (BMCs) from male
% s8 b2 u$ w+ L% y2 ], q4 E9 Pdonors [1–3]. BMC transplantation has been performed to treat
* ^7 S2 j3 c, `hematological diseases, and several clinical studies have applied3 N+ K3 W1 e" @3 c( V" S, p7 X+ X
BMC injection to induce regeneration of myocardium and blood
: |* {) S0 B( Uvessels [4]. Taken together, these findings suggest that BMCs4 b$ p9 J/ { ?# J0 |1 D, y) f
are effective sources for regenerative liver therapy. |
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发表于 2010-6-21 19:07
