2008年Cell杂志的一期不错的干细胞特刊

yusheen

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7 h& a4 ]9 @" q" [最近浏览期刊，发现2008年Cell杂志有一期干细胞研究的综述，内容非常全面，感觉对大家非常有用，可以作为教材来研究学习。下载时把文章的补充材料也下下来，供大家学习。% H3 a6 a% |1 N! ]+ h
Stem cells have two remarkable abilities: they can self-renew to keep the stem cell pool replenished, and8 W& A( ]; {. s3 B2 V& W
they can differentiate into a wide variety of cell types. This stunning biological duality intrigues not only
( J* u" u; r1 c9 u! P( lthose interested in the basic mechanisms of development, differentiation, and reprogramming, but
$ [# u  z" ]* R2 B( malso those who seek to use stem cells therapeutically to replace lost or damaged tissue. But when did
& k  G7 t7 D% e7 `the stem cell revolution start? It was back in the 1960s that two Canadian researchers, Ernest A. McCulloch- v! F" V: t. h% q( X: w4 D! i
and James E. Till, launched the field of stem cell research with their groundbreaking work on the hematopoietic
3 f3 A5 B% z) ~" n% Wstem cells of mouse bone marrow. By designing clonogenic assays to measure stem cell differentiation$ Y( j0 n0 K  ~5 s, Q8 f
in vitro and serial transplantation assays to study stem cell repopulating ability in vivo, Till and( J6 }( A; W# ~& ^# o$ v: V
McCulloch defined the hallmark characteristics of stem cells.7 a1 q2 h0 g  B) `0 v; b/ m
The field of stem cell research has come a long way in 50 years, as we hope will be apparent from this+ J& S! n0 I+ B7 g. c5 h
year’s Special Review Issue. Our goal in this issue is to highlight the remarkable biological features of
6 f6 I# ]  A' _- G! R. ostem cells, the molecular pathways that control these characteristics, and the ways in which these enigmatic9 c% y1 L7 s1 a' K- @# c
cells can be exploited for cell replacement therapy. We would like to thank the many distinguished% c1 y/ I+ d5 [/ B+ Q
experts who contributed their time and efforts as authors and reviewers to make this special issue on
$ P2 S8 f$ W/ |( o, Fstem cells informative, thought-provoking, and timely. We hope that this collection of articles conveys
) i# _2 M; I+ i) K2 ^+ U  Ythe excitement and promise of stem cell research, as we enter a new era of possibility.

yusheen

回复 yusheen 的帖子1 k0 f5 R4 L) v, z7 X
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顶一个

chuanbaozang

赞一个

exin11

看看

flydayzhu

look 一下

linlicau

辛苦了，要点包包也能理解。

ayeqiu

下载看看~

ayeqiu

为啥每次都提示“你所在的用户组无法下载或查看附件”…………晕！晕！！晕！！！……

tpwang

回复 ayeqiu 的帖子
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你的积分还差9分就可以成为注册会员了，加油。' A0 F+ E) a. ^: t- [7 Y# M
. S" U1 i" n5 j6 \2 d) V+ L$ I
参加一些讨论是增加积分的最好办法。

ayeqiu

回复 tpwang 的帖子
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原来是这样啊，谢谢你！