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本帖最后由 细胞海洋 于 2011-2-9 08:15 编辑
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2 T4 I, y$ o8 o. C8 m最近浏览期刊，发现2008年Cell杂志有一期干细胞研究的综述，内容非常全面，感觉对大家非常有用，可以作为教材来研究学习。下载时把文章的补充材料也下下来，供大家学习。
- E' h' u1 @* [" Q* r6 @, ^Stem cells have two remarkable abilities: they can self-renew to keep the stem cell pool replenished, and
4 y. I& R$ p# h, Hthey can differentiate into a wide variety of cell types. This stunning biological duality intrigues not only
! H6 J/ i3 ]2 P0 O9 tthose interested in the basic mechanisms of development, differentiation, and reprogramming, but! ~$ A5 F, L- \2 y6 s8 P% e6 e! @: D
also those who seek to use stem cells therapeutically to replace lost or damaged tissue. But when did
9 D5 m1 K% V% ?- Y# H" p. Kthe stem cell revolution start? It was back in the 1960s that two Canadian researchers, Ernest A. McCulloch
# \. H& u! s/ K) U, cand James E. Till, launched the field of stem cell research with their groundbreaking work on the hematopoietic
. }- r7 F( r2 B- Y; Dstem cells of mouse bone marrow. By designing clonogenic assays to measure stem cell differentiation Y7 B1 V1 _$ ]' T# Q
in vitro and serial transplantation assays to study stem cell repopulating ability in vivo, Till and
0 j i1 K6 z6 ` b+ AMcCulloch defined the hallmark characteristics of stem cells.$ e/ }6 M" F& T1 C
The field of stem cell research has come a long way in 50 years, as we hope will be apparent from this
4 s, s5 z2 l6 ~! \1 D! eyear’s Special Review Issue. Our goal in this issue is to highlight the remarkable biological features of3 }0 T, P* p& j7 z
stem cells, the molecular pathways that control these characteristics, and the ways in which these enigmatic
. C9 _2 i: _5 o3 a, c& Ucells can be exploited for cell replacement therapy. We would like to thank the many distinguished2 x' ^" {5 D1 q
experts who contributed their time and efforts as authors and reviewers to make this special issue on6 c5 t+ [* I* g* ]) A9 X
stem cells informative, thought-provoking, and timely. We hope that this collection of articles conveys
, Z4 u E1 h7 C; _the excitement and promise of stem cell research, as we enter a new era of possibility. |
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发表于 2011-2-8 23:40
发表于 2011-2-9 09:33
