2008年Cell杂志的一期不错的干细胞特刊

yusheen

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最近浏览期刊，发现2008年Cell杂志有一期干细胞研究的综述，内容非常全面，感觉对大家非常有用，可以作为教材来研究学习。下载时把文章的补充材料也下下来，供大家学习。$ o2 G+ |* O- r/ c8 d; c& A
Stem cells have two remarkable abilities: they can self-renew to keep the stem cell pool replenished, and; y6 ~' z. j; P( Q: w+ O  @) H5 u1 q" p
they can differentiate into a wide variety of cell types. This stunning biological duality intrigues not only
. ~. \  K' m8 A2 m: Ethose interested in the basic mechanisms of development, differentiation, and reprogramming, but- O0 G% {3 a$ d8 i# O5 _
also those who seek to use stem cells therapeutically to replace lost or damaged tissue. But when did& ]- }0 i8 `3 B9 M0 f/ h
the stem cell revolution start? It was back in the 1960s that two Canadian researchers, Ernest A. McCulloch
2 M) A0 O, F7 K! c. |) r) cand James E. Till, launched the field of stem cell research with their groundbreaking work on the hematopoietic
' E0 f/ o2 G6 d1 Cstem cells of mouse bone marrow. By designing clonogenic assays to measure stem cell differentiation6 @8 U3 q1 b+ x& o& m, M% B3 ^1 _
in vitro and serial transplantation assays to study stem cell repopulating ability in vivo, Till and
7 s- C1 s2 [7 q: `McCulloch defined the hallmark characteristics of stem cells.
& }8 ^. S0 W/ s) o. EThe field of stem cell research has come a long way in 50 years, as we hope will be apparent from this9 s$ d8 _$ x3 n$ e- `
year’s Special Review Issue. Our goal in this issue is to highlight the remarkable biological features of
- U' K' l1 E5 o' \( Ustem cells, the molecular pathways that control these characteristics, and the ways in which these enigmatic9 a* n8 i, f/ t
cells can be exploited for cell replacement therapy. We would like to thank the many distinguished
* ]2 `. u7 J5 ?% m1 Jexperts who contributed their time and efforts as authors and reviewers to make this special issue on
# H7 f- e/ a+ M/ r% Z" j$ S! Z) }# Fstem cells informative, thought-provoking, and timely. We hope that this collection of articles conveys  l+ e7 t) `2 Z7 N
the excitement and promise of stem cell research, as we enter a new era of possibility.

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