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本帖最后由 qgjin 于 2010-5-10 00:42 编辑
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0 X" I8 W# }9 S* U; x) q CDerivation of Oocytes from Mouse Embryonic Stem Cells
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Karin Hu¨bner,1 Guy Fuhrmann,3 Lane K. Christenson,4 James Kehler,1 Rolland Reinbold,1 Rabindranath De La Fuente,2 Jennifer Wood,4 Jerome F. Strauss III,4 Michele Boiani,1 Hans R. Scho¨ler1** z. |2 v% a% n
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' ?$ y1 R" A$ i3 a( \Continuation of mammalian species requires the formation and development of the sexually dimorphic germ cells. Cultured embryonic stem cells are generally
+ g9 l+ a; Y @* S J/ zconsidered pluripotent rather than totipotent because of the failure to detect germline cells under differentiating conditions. Here we show that1 j3 g% I$ a' t; d- c
mouse embryonic stem cells in culture can develop into oogonia that enter meiosis, recruit adjacent cells to form follicle-like structures, and later develop4 Z+ Y/ i, [! d9 ]2 O! `
into blastocysts. Oogenesis in culture should contribute to various areas, including nuclear transfer and manipulation of the germ line, and advance studies1 B1 c" K( s4 J3 p3 m- m
on fertility treatment and germ and somatic cell interaction and differentiation. |
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发表于 2010-5-10 00:37
发表于 2010-10-26 09:56
