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本帖最后由 qgjin 于 2010-5-10 00:42 编辑 ; f: l3 G% p4 y. ~! s
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Derivation of Oocytes from Mouse Embryonic Stem Cells
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% X2 ~* f, h9 {; c! Q8 w }Karin Hu¨bner,1 Guy Fuhrmann,3 Lane K. Christenson,4 James Kehler,1 Rolland Reinbold,1 Rabindranath De La Fuente,2 Jennifer Wood,4 Jerome F. Strauss III,4 Michele Boiani,1 Hans R. Scho¨ler1* v9 x; E$ O! T2 O% ?1 r
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+ N5 r6 V5 \5 O6 D- Y9 [' CContinuation of mammalian species requires the formation and development of the sexually dimorphic germ cells. Cultured embryonic stem cells are generally
2 x5 L$ R3 N7 h6 z& d% Pconsidered pluripotent rather than totipotent because of the failure to detect germline cells under differentiating conditions. Here we show that; _8 j3 M6 v, L% ?* k S
mouse embryonic stem cells in culture can develop into oogonia that enter meiosis, recruit adjacent cells to form follicle-like structures, and later develop
$ p- w* q6 Z4 }$ n$ cinto blastocysts. Oogenesis in culture should contribute to various areas, including nuclear transfer and manipulation of the germ line, and advance studies
+ Q8 _4 u4 Z1 y$ oon fertility treatment and germ and somatic cell interaction and differentiation. |
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发表于 2010-5-10 00:37
发表于 2010-10-26 09:56
