|
 
- 积分
- 302
- 威望
- 302
- 包包
- 311
|
本帖最后由 qgjin 于 2010-5-10 00:42 编辑
) ^4 Y; q4 h8 w6 ~. _1 E" F( G1 h# G6 f
Derivation of Oocytes from Mouse Embryonic Stem Cells
% @0 o, n! ]" D4 \. [2 M Z9 D; r9 K! w+ n" T1 J1 W3 r; b% d' t
Karin Hu¨bner,1 Guy Fuhrmann,3 Lane K. Christenson,4 James Kehler,1 Rolland Reinbold,1 Rabindranath De La Fuente,2 Jennifer Wood,4 Jerome F. Strauss III,4 Michele Boiani,1 Hans R. Scho¨ler1*7 x! w4 i# V, E5 ~4 K# ~( _: h
2 a4 r% T. g2 Q5 x
/ \9 m- @% _* `8 r/ bContinuation of mammalian species requires the formation and development of the sexually dimorphic germ cells. Cultured embryonic stem cells are generally
/ ?2 V- T4 i5 X% i; kconsidered pluripotent rather than totipotent because of the failure to detect germline cells under differentiating conditions. Here we show that
* [% @( }3 e3 X0 U/ Cmouse embryonic stem cells in culture can develop into oogonia that enter meiosis, recruit adjacent cells to form follicle-like structures, and later develop; y- E" z% ^ u: D8 ]. N3 J; G
into blastocysts. Oogenesis in culture should contribute to various areas, including nuclear transfer and manipulation of the germ line, and advance studies
, J; D/ [7 `6 ron fertility treatment and germ and somatic cell interaction and differentiation. |
附件: 你需要登录才可以下载或查看附件。没有帐号？注册
-
总评分: 威望 + 6
包包 + 12
查看全部评分
|
发表于 2010-5-10 00:37
发表于 2010-10-26 09:56
