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Nat Rev Mol Cell Biol. 2008 Jan;9(1):82-8.* k; p# a$ \) p" E/ r' z- x; m4 d
Epidermal homeostasis: do committed progenitors work while stem cells sleep?
' ?" _( G; o% U7 }, iJones P, Simons BD.: A/ x* D# I2 v$ ?! n3 U5 `, k' f: l7 _
Source
& j) [0 x' [/ O: p) x F+ JPhilip Jones is at the MRC Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge, CB2 2XZ, UK. phj20@hutchison-mrc.cam.ac.uk
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Abstract
7 } v$ R- E- }Tracking the fate of cells in murine epidermis in vivo has revealed that a committed progenitor cell population can maintain normal adult tissue in the long term without support from a long-lived, self-renewing population of stem cells. Here, we argue that these results challenge the dogma that stem-cell proliferation is required for the cellular homeostasis of the epidermis and other adult tissues, with important implications for tissue physiology and disease.4 ~; s: b0 n9 d' B
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http://www.ncbi.nlm.nih.gov/pubmed?term=Epidermal%20homeostasis%3A%20do%20committed%20progenitors%20work%20while%20stem%20cells%20sleep%3F%20 |
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