求助nature Review一篇文章

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Nat Rev Mol Cell Biol. 2008 Jan;9(1):82-8.
5 ]$ d8 c6 C" D6 h( L# xEpidermal homeostasis: do committed progenitors work while stem cells sleep?. ^) T" w. ]8 J
Jones P, Simons BD.
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% |& R7 Z/ e- k/ Z, aPhilip Jones is at the MRC Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge, CB2 2XZ, UK. phj20@hutchison-mrc.cam.ac.uk5 R4 {0 f3 |9 y. _; ]8 w

7 U4 A8 M8 k+ b( L# h3 jAbstract/ X& |! C: j/ |
Tracking the fate of cells in murine epidermis in vivo has revealed that a committed progenitor cell population can maintain normal adult tissue in the long term without support from a long-lived, self-renewing population of stem cells. Here, we argue that these results challenge the dogma that stem-cell proliferation is required for the cellular homeostasis of the epidermis and other adult tissues, with important implications for tissue physiology and disease.
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9 \8 n- f2 l( [http://www.ncbi.nlm.nih.gov/pubmed?term=Epidermal%20homeostasis%3A%20do%20committed%20progenitors%20work%20while%20stem%20cells%20sleep%3F%20

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