求助nature Review一篇文章

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Nat Rev Mol Cell Biol. 2008 Jan;9(1):82-8.
# T0 V1 o) {/ \3 s) K$ F# v) cEpidermal homeostasis: do committed progenitors work while stem cells sleep?. b# X1 W  K+ m% d3 _0 L4 ]& ~
Jones P, Simons BD.
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Philip Jones is at the MRC Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge, CB2 2XZ, UK. phj20@hutchison-mrc.cam.ac.uk, k" V6 A7 ^0 K' `* L

( Z0 s1 \" e$ z  hAbstract
, ^/ A! Y4 b4 V- H. r3 s- _Tracking the fate of cells in murine epidermis in vivo has revealed that a committed progenitor cell population can maintain normal adult tissue in the long term without support from a long-lived, self-renewing population of stem cells. Here, we argue that these results challenge the dogma that stem-cell proliferation is required for the cellular homeostasis of the epidermis and other adult tissues, with important implications for tissue physiology and disease.
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http://www.ncbi.nlm.nih.gov/pubmed?term=Epidermal%20homeostasis%3A%20do%20committed%20progenitors%20work%20while%20stem%20cells%20sleep%3F%20

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