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Cancer Res. 2013 Aug 2. [Epub ahead of print]
0 `- \. Y N' ~! \: R& Cp63, Sharp1, and HIFs: Master Regulators of Metastasis in Triple-Negative Breast Cancer.
6 m" l6 d& {4 o$ ^0 KPiccolo S, Enzo E, Montagner M., y( j% h' h7 n0 z% Q5 A0 l3 v# w
Source
6 q2 k' V6 ]3 P XAuthors' Affiliation: Department of Molecular Medicine, School of Medicine, University of Padua, Padua, Italy.6 L6 L& _: @( ~
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Abstract
' Q9 ^2 Q" Z) H) E# b9 @0 TMetastasis is the most significant cause of cancer-associated morbidity and mortality but remains poorly understood. Recent work revealed that metastasis of aggressive triple-negative breast cancers is suppressed by Sharp1, a factor that promotes degradation of hypoxia-inducible factors (HIF) and blunts HIF-induced malignant cell behavior. Cancer Res; 73(16); 1-4. ©2013 AACR.
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8 D2 U' b2 k/ M6 G2 P& M1 HPMID: 23913939 [PubMed - as supplied by publisher]" k7 Q1 U4 u3 k- ]
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发表于 2013-8-8 23:25
