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本帖最后由 饶冠华 于 2009-5-12 11:12 编辑
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* _4 M q ^- W! s/ H; dTheories of carcinogenesis
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1. The somatic mutation theory (SMT) has been the prevailing one in cancer research for the last 50 years . It is based on the following premises: (1) cancer is derived from a single somatic cell that successively has accumulated multiple DNA mutations (monoclonality), (2) those mutations occur on genes that control cell proliferation and the cell cycle ,and (3) implicitly, the default state of cell proliferation in metazoa is quiescence.4 G$ S9 S- q% B6 h, w4 O# R
, d# X6 N' ]0 p X8 [2. The aneuploidy theory of carcinogenesis, S/ `/ }9 f! i3 P2 r# l, G
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