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本帖最后由 细胞海洋 于 2013-3-29 18:59 编辑 ; B5 P' m& j$ \" Y9 B% W
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- H6 t8 U- M# {+ C1 c. ]. I* R+ J3 lVolume 153, Issue 1
; K# v+ O/ [. N. w' W! m6 ^. D. i& ]On the cover: The kind of food an organism consumes has a broad reaching
. t1 P% K I0 E/ ?8 [5 Oimpact on its development, behavior, and lifespan. In this issue, two
+ ^3 L& @% D e( K3 e+ Z: Wpapers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore
% X5 h# ]4 Y4 S( \the effects of diet on these life-history traits in the nematode C.
0 u5 U, e1 l* celegans. Combining nutrigenomics and network analyses, they find that " u: J* T+ F2 x. J. @5 U
different diets affect traits via distinct mechanisms. The response to diet is 5 o) V' W8 B& W5 l) \8 t# N% w J
coupled to metabolic changes, and disruptions of some of these specific
\' c) z* v' B! X/ u2 ?metabolic pathways correspond to inborn errors of metabolism in humans. The
& B9 |* A+ f5 g2 C, k8 m) wcover features a “native-art-inspired abstraction” of a worm eating a bacterial
6 q6 }8 d$ k" y4 Q! ?5 d1 S+ C& _/ ]diet and illustrates the interconnectedness between diet, nuclear gene
7 k5 i y, W/ h/ o4 j7 u* gregulatory networks, mitochondrial networks, and their effects on life-history
* ]; L$ l# Z. |& [* C6 t, qtraits such as development and brood size. Cover art by Lesley T. MacNeil.
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发表于 2013-3-29 13:31
发表于 2013-3-29 23:38
