《细胞》[Cell]13年3月28日出版pdf全文

nero1981

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Volume 153, Issue 10 G; P- U* I( }& m
On the cover: The kind of food an organism consumes has a broad reaching
9 A; p2 H7 H4 k0 f6 T9 qimpact on its development, behavior, and lifespan. In this issue, two / }; h, {% H1 y5 ~+ h
papers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore
' J& L- J6 p# e5 l6 Kthe effects of diet on these life-history traits in the nematode C. # G0 c. |" ?  [& _
elegans. Combining nutrigenomics and network analyses, they find that
* d2 J" k7 Q2 ^& ^2 J7 @8 ndifferent diets affect traits via distinct mechanisms. The response to diet is 0 x' v8 T; p! b
coupled to metabolic changes, and disruptions of some of these specific / y1 y" g/ V0 w( |
metabolic pathways correspond to inborn errors of metabolism in humans. The
* R$ c* }# F; S5 Z- n4 B+ H, K1 Mcover features a “native-art-inspired abstraction” of a worm eating a bacterial & V) v. e! V0 W* |8 l9 y
diet and illustrates the interconnectedness between diet, nuclear gene
( P1 C$ U' Z8 z6 n& G( L4 d3 kregulatory networks, mitochondrial networks, and their effects on life-history
9 J+ z! M# I% F% e0 h4 }5 Btraits such as development and brood size. Cover art by Lesley T. MacNeil.
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