《细胞》[Cell]13年3月28日出版pdf全文

nero1981

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5 h1 s1 Z2 v. IVolume 153, Issue 1* q  ]: s6 N% s# U  c4 X
On the cover: The kind of food an organism consumes has a broad reaching 1 K0 o# Z5 X: i3 H5 t
impact on its development, behavior, and lifespan. In this issue, two 2 w+ C$ `" a0 g+ M3 X. \3 K
papers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore ; @" [9 B( C9 m8 |9 h( Y
the effects of diet on these life-history traits in the nematode C. 0 ^, `3 j2 z% Y) ?* A0 V
elegans. Combining nutrigenomics and network analyses, they find that ; T  q  _( g: u5 \; A
different diets affect traits via distinct mechanisms. The response to diet is
' O  `# Q  e& @+ P$ Ocoupled to metabolic changes, and disruptions of some of these specific 2 i# {: ~) ?; B$ l
metabolic pathways correspond to inborn errors of metabolism in humans. The
, j/ R. ?3 |7 pcover features a “native-art-inspired abstraction” of a worm eating a bacterial ' K% L" J% y5 i+ D; D( U3 C
diet and illustrates the interconnectedness between diet, nuclear gene
" K$ B% X# W, n. S9 ~3 rregulatory networks, mitochondrial networks, and their effects on life-history
0 O1 A3 k+ Y6 N5 `' q% straits such as development and brood size. Cover art by Lesley T. MacNeil.
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