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- ?5 }; m5 @0 u [: BVolume 149, Issue 27 T. g4 S; M: M7 c
On the cover: Congenital scoliosis is a human birth defect that results in
! e4 y! v7 t, E) ~! ]) t6 [0 C) Cspinal curvature caused by vertebral defects. In this issue, Sparrow et al. (pp. 5 ?& R+ ]+ ^ G2 [- Z+ s$ j4 g! z
295–306) demonstrate that such defects in humans and mice can be caused by
: s' F- O- `. O9 z) U6 yhaploinsufficiency of Notch signaling pathway genes. In mice, this genetic risk & o( r+ N9 d) V6 L- N1 i* h
factor combined with an environmental condition (short-term hypoxia) , a& _! L5 z8 A- G' M! X/ }
significantly increases the penetrance and severity of vertebral defects. The
$ Y$ R0 z& E: `8 ucover photograph shows severe vertebral and rib defects of an embryonic mouse + L0 |" C$ `' C1 J7 p) w' v
containing a null allele of a Notch signaling pathway target gene and exposed to 9 e0 t: Z3 s5 L) I8 J. ?3 U2 O
a brief period of hypoxia during gestation.
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4 V. e1 j% Q$ n' H B/ a0 F[hide][/hide] |
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