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本帖最后由 细胞海洋 于 2012-4-13 22:22 编辑
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Volume 149, Issue 2" c2 f" k; K; z4 T
On the cover: Congenital scoliosis is a human birth defect that results in
) _! J3 l. h' d4 R- s& k( l8 S% \spinal curvature caused by vertebral defects. In this issue, Sparrow et al. (pp. ( m3 O5 i% Q5 t
295–306) demonstrate that such defects in humans and mice can be caused by 1 A4 z6 k( @% }4 g
haploinsufficiency of Notch signaling pathway genes. In mice, this genetic risk
( s! z5 q8 x: F3 Rfactor combined with an environmental condition (short-term hypoxia)
' i* D& @( s% {8 }" x# tsignificantly increases the penetrance and severity of vertebral defects. The 5 ~5 I7 G) |. u" r! }
cover photograph shows severe vertebral and rib defects of an embryonic mouse * J/ ]6 J- v- |' i7 O: ?& t( v
containing a null allele of a Notch signaling pathway target gene and exposed to
4 v8 T: l1 K2 ~2 X& Ea brief period of hypoxia during gestation.
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发表于 2012-4-13 13:28
发表于 2012-4-15 15:10
