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本帖最后由 细胞海洋 于 2012-4-13 22:22 编辑 ( i j4 m, H& G6 j6 P
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Volume 149, Issue 2
+ f. @) O0 ~- W- E7 I2 m. C( I6 NOn the cover: Congenital scoliosis is a human birth defect that results in 3 P, t0 z E) B# Z. [8 N
spinal curvature caused by vertebral defects. In this issue, Sparrow et al. (pp. 8 K+ q! L# r) H6 Q, M7 W
295–306) demonstrate that such defects in humans and mice can be caused by
" N: S. m. h1 z6 X) ^% Nhaploinsufficiency of Notch signaling pathway genes. In mice, this genetic risk
+ g3 \: W, M( C8 F: \# O2 cfactor combined with an environmental condition (short-term hypoxia)
# X" ?5 {8 {6 f) msignificantly increases the penetrance and severity of vertebral defects. The
+ x% i2 l+ Z8 a! c& Tcover photograph shows severe vertebral and rib defects of an embryonic mouse
8 D$ P" s+ I1 t5 }( M9 _. Z. Qcontaining a null allele of a Notch signaling pathway target gene and exposed to
# o' ^, k; k& a6 ^* Ya brief period of hypoxia during gestation.
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发表于 2012-4-13 13:28
发表于 2012-4-15 15:10
