《细胞》[Cell]13年4月25日出版pdf全文

nero1981

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Volume 153, Issue 3
/ D8 W' |( k5 q3 t& ?; hOn the cover: DNA methylation (5mC) patterns are established and maintained / J7 S) u  G. U' Y5 G8 ^* H2 r
by DNA methyltransferases. Removing methyl modifications requires a multistep & y  }  {3 P$ S
process. Iterative oxidation of 5mC by TET proteins generates
. [% U- d3 R2 Z7 O: p5 [5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine
" R# p1 j0 G  ]% s: B" X% q# N" x(5caC). 5fC/5caC can be excised by thymine-DNA glycosylase (TDG) and repaired to
, Y7 I7 Y" }9 N0 w0 Pregenerate unmodified cytosines to complete the methylation and demethylation ! c* I9 t  t1 X* _  |8 @" y
cycle. In this issue, Shen et al. (pp. 692–706) provide a genome-wide view of . ~* ^: [5 i% j
iterative 5mC oxidation dynamics in mouse embryonic stem cells. Their results 2 S1 f6 G) n" Z
indicate that TET/TDG-dependent active DNA demethylation occurs extensively in
3 @6 Q, f6 w6 b) S0 H& |: sthe mammalian genome. In a related paper, Song et al. (pp. 678–691) look at the
8 M& V) b* h6 Kcontribution of 5mC oxidized states to epigenetic tuning at regulatory elements. " [3 H% B" Q& ^- P4 W( m
The cyclist on the cover illustrates the cyclic change of cytosine . _8 l! R, h$ g* Z  K/ P6 J
modifications. Artwork by Li Shen and Yi Zhang.
8 z: Z$ \5 ^' h2 Z* ~# V[hide][/hide]

懵懂干细胞

辛苦了

yuheng

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exin11

86964109

谢谢^^

nydfy

thanks

小小元分

kouke80

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vivipet

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tpwang

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