presentation nanog gateway （原创）请指教~

flydayzhu

8 B0 g, _1 ~4 X
欢迎大家交流，对后面Xi的部分不是很懂，请指教~

lixiaodong

Nanog is cloned by Smith A and Yamanaka S' groups almost at the same time in 2003 (two cell papers). Smith A's group also studied Oct4 () and BMP(). The question is about a recent cell paper by Smith A's group in Cell. According the that paper: "Nanog can command constitutive self-renewal of ES cells (Chambers et al., 2003) and appears able to reverse precommitment: i- P& a) g) ~: z! h$ G7 \
perturbations of the pluripotent state. Nanog also greatly increases the efficiency of nuclear reprogramming by6 G4 q1 {; J" ?- Y: {$ b3 Q/ K' g- T2 ]
ES cell fusion. It is therefore somewhat surprising that Nanog is not represented among the minimal combinations of exogenous factors found to convert mouse somatic cells into iPS cells. This study offers an explanation. Our results indicate& y" H2 w/ p$ Z% h, t5 B+ P1 e
that Nanog is in fact decisive for attaining this pluripotent ground state. However, this requirement is during the final phase of reprogramming when other key factors are already present and may be fulfilled by activation of endogenous Nanog. A role in8 `) l; j3 a5 q* o5 d  ?0 ^+ F
the culmination of somatic cell reprogramming is mirrored by the pivotal function revealed for Nanog in establishing pluripotency
/ X/ i/ x* y/ l- Din the embryo."* [, n* S+ O$ P+ r* B( i5 J6 Y& c7 n- N
Hope those papers are helpful to understand the background information for discussion.