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本帖最后由 qgjin 于 2010-5-10 00:42 编辑 / T: k4 c* Y' E3 z. }6 E; E
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Derivation of Oocytes from Mouse Embryonic Stem Cells! X6 a! ^0 W/ |
/ j: Q7 c, ?6 C$ U7 {Karin Hu¨bner,1 Guy Fuhrmann,3 Lane K. Christenson,4 James Kehler,1 Rolland Reinbold,1 Rabindranath De La Fuente,2 Jennifer Wood,4 Jerome F. Strauss III,4 Michele Boiani,1 Hans R. Scho¨ler1*
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( B0 A1 I! i( U) z- ?# BContinuation of mammalian species requires the formation and development of the sexually dimorphic germ cells. Cultured embryonic stem cells are generally$ W. d$ e1 {' M+ e. Y6 }1 T. n! Z
considered pluripotent rather than totipotent because of the failure to detect germline cells under differentiating conditions. Here we show that1 @7 _- _: t' p: K4 ]" p
mouse embryonic stem cells in culture can develop into oogonia that enter meiosis, recruit adjacent cells to form follicle-like structures, and later develop6 T5 b0 Z# T, `" X0 u! ^# d
into blastocysts. Oogenesis in culture should contribute to various areas, including nuclear transfer and manipulation of the germ line, and advance studies$ h. c; y3 B! w# o7 ?! ?8 S
on fertility treatment and germ and somatic cell interaction and differentiation. |
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