端粒酶综述-1

gemstone

A ‘higher order’ of telomere regulation: telomere
& t/ n3 i3 V) w, }heterochromatin and telomeric RNAs
2 Y8 ^9 _) L  {* L% l1 _3 B; N8 N; L  p% z6 W  `/ D: @
EMBO  2009
- x! m# g5 y" {8 u# Z# `8 {1 AProtection of chromosome ends from DNA repair and4 q. r8 e7 }; W- B# W4 i
degradation activities is mediated by specialized protein0 _% V, e7 s" ^5 P
complexes bound to telomere repeats. Recently, it has
5 X( U/ c/ L9 e6 Nbecome apparent that epigenetic regulation of the+ \7 O. |8 x! U
telomeric chromatin template critically impacts on
/ U( s' ?' {. N3 o" X; B$ o  ?* @1 }telomere function and telomere-length homeostasis from; F6 C3 W" o+ X1 G
yeast to man. Across all species, telomeric repeats as well' U; Z' F5 v2 s& x! I
as the adjacent subtelomeric regions carry features of
6 Z# M8 _# W5 I; e  Y& W" H2 Brepressive chromatin. Disruption of this silent chromatin2 l% G- v- ?" L, T
environment results in loss of telomere-length control
+ j! F: P- P4 Wand increased telomere recombination. In turn, progressive2 g$ e0 ~" r+ f! d: A+ l
telomere loss reduces chromatin compaction at
, |. C" y  s0 t- Y# ]telomeric and subtelomeric domains. The recent discoveries
7 P  X# Z# e: @; Nof telomere chromatin regulation during early mammalian6 A0 O+ Z; q, E+ |5 _" y+ r/ }
development, as well as during nuclear
, s9 n" u4 w6 Greprogramming, further highlights a central role of telomere
& p+ z/ G  F: M3 N; D7 x# W' _chromatin changes in ontogenesis. In addition,
' }" ]6 K" b6 \- q; C; }telomeres were recently shown to generate long, noncoding
  @7 J1 D' E% X/ s4 w! h& ?- q( z0 VRNAs that remain associated to telomeric chromatin+ V; n, a3 c9 ~1 J/ z' f' W
and will provide new insights into the regulation of1 u  L4 l* ]0 d& N) S' L; b
telomere length and telomere chromatin. In this review,8 K1 P2 B% m1 b2 k" H
we will discuss the epigenetic regulation of telomeres) W2 |' I$ F7 B# Q# B& T) L5 W
across species, with special emphasis on mammalian% i" @- F- m, o( c; s5 s& v7 @$ O$ Y
telomeres. We will also discuss the links between
& F+ Q1 L; q' k6 g$ Oepigenetic alterations at mammalian telomeres and
9 s" q2 q" U2 x) K5 Atelomere-associated diseases.

aminophylline

谢谢分享！！！

askage

谢谢老兄

gemstone

不用客气！欢迎交流！

missyoudad

谢谢版主

istephen

感谢楼主分享

天地之间

谢谢

peak0311

谢谢楼主分享