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这里有一张关于小鼠生殖的图片:
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: ]( l! w4 o, g; L% fMouse spermatogenic lineage. When a spermatogonial stem cell (type As spermatogonia) divides, daughter cells can remain type As
. F2 p9 U% X7 q/ W6 Cspermatogonia (self-renewal) or commit to differentiation, giving rise through 12 amplifying divisions (212) to a clone of spermatogenesis that could) M% m/ m1 s7 E. O& P+ b
theoretically contain 4,096 spermatozoa. Once committed to differentiation, an As spermatogonial stem cell gives rise to a pair of undifferentiated
9 w) m2 P# L# J: F, [spermatogonia (Apr) that are connected by a cytoplasmic bridge. Incomplete cytokinesis is a hallmark of germ cell proliferation. The first four5 ?& M' y( P* Z
population doubling divisions (21–24) generate chains of undifferentiated Apr and Aal spermatogonia; Apr, Aal4, Aal8, Aal16, which collectively make
* s$ O" b; T" n& p/ dup the pool of progenitor spermatogonia. Differentiation becomes evident morphologically when a chain of Aal16 spermatogonia becomes a chain of+ p; G* ?( A5 z3 R) e9 a( m
type A116 spermatogonia. The next five population doubling divisions (25–29) generate types A2, A3, A4, intermediate, and B differentiating
3 M ^! M9 {4 r. B% K9 Mspermatogonia. The 10th division (210) produces primary spermatocytes (4N) and is followed by two meiotic divisions (211–212) and spermiogenesis5 Z7 u& [% O) y) A$ Y3 A
to produce 1N, terminally differentiated spermatozoa. Abbreviations: Aal, Aaligned; Apr, Apaired; As, Asingle. |
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