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这里有一张关于小鼠生殖的图片:
# [8 p4 T& g$ i+ ^) R% i) W0 @6 V、
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Mouse spermatogenic lineage. When a spermatogonial stem cell (type As spermatogonia) divides, daughter cells can remain type As
) k8 I+ T. R7 Rspermatogonia (self-renewal) or commit to differentiation, giving rise through 12 amplifying divisions (212) to a clone of spermatogenesis that could. E: u; G. B( K
theoretically contain 4,096 spermatozoa. Once committed to differentiation, an As spermatogonial stem cell gives rise to a pair of undifferentiated, w9 ~' O/ l: P& _+ p
spermatogonia (Apr) that are connected by a cytoplasmic bridge. Incomplete cytokinesis is a hallmark of germ cell proliferation. The first four
. Q0 P' _+ ?9 g3 l3 Gpopulation doubling divisions (21–24) generate chains of undifferentiated Apr and Aal spermatogonia; Apr, Aal4, Aal8, Aal16, which collectively make) V: C. `0 B9 n, U
up the pool of progenitor spermatogonia. Differentiation becomes evident morphologically when a chain of Aal16 spermatogonia becomes a chain of
+ T5 x+ I7 L2 X h9 M: Stype A116 spermatogonia. The next five population doubling divisions (25–29) generate types A2, A3, A4, intermediate, and B differentiating+ q% ?3 j- F, r8 m& {+ U% H/ ?
spermatogonia. The 10th division (210) produces primary spermatocytes (4N) and is followed by two meiotic divisions (211–212) and spermiogenesis
2 @ N8 x3 m( \/ pto produce 1N, terminally differentiated spermatozoa. Abbreviations: Aal, Aaligned; Apr, Apaired; As, Asingle. |
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