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这里有一张关于小鼠生殖的图片:
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. G$ U0 K; G1 h i, X- l5 |Mouse spermatogenic lineage. When a spermatogonial stem cell (type As spermatogonia) divides, daughter cells can remain type As
0 [7 M/ G0 Z8 [" \6 G' A; G1 hspermatogonia (self-renewal) or commit to differentiation, giving rise through 12 amplifying divisions (212) to a clone of spermatogenesis that could: A/ Z% n! y$ b3 ]- C5 E
theoretically contain 4,096 spermatozoa. Once committed to differentiation, an As spermatogonial stem cell gives rise to a pair of undifferentiated
? ]) |+ K: P; l: t H9 Ispermatogonia (Apr) that are connected by a cytoplasmic bridge. Incomplete cytokinesis is a hallmark of germ cell proliferation. The first four
* z6 U+ }8 z2 E$ n9 bpopulation doubling divisions (21–24) generate chains of undifferentiated Apr and Aal spermatogonia; Apr, Aal4, Aal8, Aal16, which collectively make
3 U! n1 w! s8 n0 w; ?! [up the pool of progenitor spermatogonia. Differentiation becomes evident morphologically when a chain of Aal16 spermatogonia becomes a chain of- G# R0 Y2 t1 q
type A116 spermatogonia. The next five population doubling divisions (25–29) generate types A2, A3, A4, intermediate, and B differentiating
2 F# J! v9 w4 g. _spermatogonia. The 10th division (210) produces primary spermatocytes (4N) and is followed by two meiotic divisions (211–212) and spermiogenesis
, h, Z3 p2 o) Sto produce 1N, terminally differentiated spermatozoa. Abbreviations: Aal, Aaligned; Apr, Apaired; As, Asingle. |
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