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本帖最后由 qgjin 于 2010-5-10 00:42 编辑
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" Y! F, U$ o6 N. j. ADerivation of Oocytes from Mouse Embryonic Stem Cells
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e! g, K2 ?; T5 m& \" n* nKarin Hu¨bner,1 Guy Fuhrmann,3 Lane K. Christenson,4 James Kehler,1 Rolland Reinbold,1 Rabindranath De La Fuente,2 Jennifer Wood,4 Jerome F. Strauss III,4 Michele Boiani,1 Hans R. Scho¨ler1*
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: r& {' K5 U. _1 k1 t) JContinuation of mammalian species requires the formation and development of the sexually dimorphic germ cells. Cultured embryonic stem cells are generally
6 F5 L: \5 `3 Z/ [% tconsidered pluripotent rather than totipotent because of the failure to detect germline cells under differentiating conditions. Here we show that
% X; a7 f9 `* O& l1 ]0 {8 N* Qmouse embryonic stem cells in culture can develop into oogonia that enter meiosis, recruit adjacent cells to form follicle-like structures, and later develop* Z- [+ j) ]) s! j5 Y& v, Q0 o
into blastocysts. Oogenesis in culture should contribute to various areas, including nuclear transfer and manipulation of the germ line, and advance studies
4 ]0 }( `) p/ V3 I& ?3 r7 Won fertility treatment and germ and somatic cell interaction and differentiation. |
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发表于 2010-5-10 00:37
发表于 2010-10-26 09:56
